RapamycinFungusV1, Main, Exploration, bibRecord, 000203

The Interferon-Gamma +874 A/T Polymorphism Is Not Associated With CMV Infection After Kidney Transplantation.

Identifieur interne : 000203 ( Main/Exploration ); précédent : 000202; suivant : 000204

The Interferon-Gamma +874 A/T Polymorphism Is Not Associated With CMV Infection After Kidney Transplantation.

Auteurs : Jose Luis Santiago [Espagne] ; Isabel Pérez-Flores [Espagne] ; Luis Sánchez-Pérez [Espagne] ; Maria Angeles Moreno De La Higuera [Espagne] ; Natividad Calvo-Romero [Espagne] ; Javier Querol-García [Espagne] ; Esther Culebras [Espagne] ; Elena Urcelay [Espagne] ; Cristina Fernández-Pérez [Espagne] ; Ana Isabel Sánchez-Fructuoso [Espagne]

Source :

Frontiers in immunology [ 1664-3224 ] ; 2019.

RBID : pubmed:31998298

Descripteurs français

KwdFr :
- Allèles (MeSH), Cytokines (génétique), Cytokines (métabolisme), Humains (MeSH), Incidence (MeSH), Infections à cytomégalovirus (diagnostic), Infections à cytomégalovirus (prévention et contrôle), Infections à cytomégalovirus (épidémiologie), Infections à cytomégalovirus (étiologie), Interféron gamma (génétique), Modèles des risques proportionnels (MeSH), Polymorphisme de nucléotide simple (MeSH), Prédisposition aux maladies (MeSH), Prédisposition génétique à une maladie (MeSH), Transplantation rénale (effets indésirables), Transplantation rénale (méthodes), Études rétrospectives (MeSH).
MESH :
- diagnostic : Infections à cytomégalovirus.
- effets indésirables : Transplantation rénale.
- génétique : Cytokines, Interféron gamma.
- métabolisme : Cytokines.
- méthodes : Transplantation rénale.
- prévention et contrôle : Infections à cytomégalovirus.
- épidémiologie : Infections à cytomégalovirus.
- étiologie : Infections à cytomégalovirus.
- Allèles, Humains, Incidence, Modèles des risques proportionnels, Polymorphisme de nucléotide simple, Prédisposition aux maladies, Prédisposition génétique à une maladie, Études rétrospectives.

English descriptors

KwdEn :
- Alleles (MeSH), Cytokines (genetics), Cytokines (metabolism), Cytomegalovirus Infections (diagnosis), Cytomegalovirus Infections (epidemiology), Cytomegalovirus Infections (etiology), Cytomegalovirus Infections (prevention & control), Disease Susceptibility (MeSH), Genetic Predisposition to Disease (MeSH), Humans (MeSH), Incidence (MeSH), Interferon-gamma (genetics), Kidney Transplantation (adverse effects), Kidney Transplantation (methods), Polymorphism, Single Nucleotide (MeSH), Proportional Hazards Models (MeSH), Retrospective Studies (MeSH).
MESH :
- chemical , genetics : Cytokines, Interferon-gamma.
- chemical , metabolism : Cytokines.
- adverse effects : Kidney Transplantation.
- diagnosis : Cytomegalovirus Infections.
- epidemiology : Cytomegalovirus Infections.
- etiology : Cytomegalovirus Infections.
- methods : Kidney Transplantation.
- prevention & control : Cytomegalovirus Infections.
- Alleles, Disease Susceptibility, Genetic Predisposition to Disease, Humans, Incidence, Polymorphism, Single Nucleotide, Proportional Hazards Models, Retrospective Studies.

Abstract

The +874 A/T polymorphism in the interferon gamma (IFNG) gene has been associated with Cytomegalovirus (CMV) infection risk in lung and kidney transplant recipients. To replicate this association, we performed a retrospective observational study of this polymorphism and immunosuppressive therapies considering the prophylactic treatment in 600 consecutive kidney transplanted recipients. We found no association of the aforementioned polymorphism with CMV infection in univariate and multivariate analyses regardless of the prophylactic treatment. In addition, the immunosuppressive treatment with mammalian target of rapamycin inhibitors (imTOR) showed a protective effect in all patients independently of prophylaxis. Moreover, in the adjusted model, we found interactions between prophylaxis with high-risk (Donor+/Recipient-, D+/R-) status (p-interaction = 0.01), with thymoglobulin induction therapy (p-interaction = 0.03) and with thymoglobulin anti-rejection therapy (p-interaction = 0.002). Data also revealed that prophylaxis was not an advantage in the not D+/R- and without thymoglobulin therapy group (HR = 0.98, p = 0.95). The benefit of prophylaxis was observed in all groups with thymoglobulin therapy, but it was maximal in the high-risk CMV infection group with both thymoglobulin induction therapy and thymoglobulin anti-rejection therapy (HR = 0.01, p < 0.001). In conclusion, the IFNG +874 polymorphism is not a predictive marker of CMV infection. The protective effect of imTOR is not improved with prophylaxis. Interestingly, the thymoglobulin therapy associated with prophylaxis is not a risk factor for CMV infection, and prophylaxis is not effective in recipients with no high-risk CMV status and without thymoglobulin therapy.

DOI: 10.3389/fimmu.2019.02994
PubMed: 31998298
PubMed Central: PMC6961530

Affiliations:

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to stream Main, to step Curation: 000130

Le document en format XML

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<country xml:lang="fr">Espagne</country>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Moreno De La Higuera, Maria Angeles" sort="Moreno De La Higuera, Maria Angeles" uniqKey="Moreno De La Higuera M" first="Maria Angeles" last="Moreno De La Higuera">Maria Angeles Moreno De La Higuera</name>
<affiliation wicri:level="4"><nlm:affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Calvo Romero, Natividad" sort="Calvo Romero, Natividad" uniqKey="Calvo Romero N" first="Natividad" last="Calvo-Romero">Natividad Calvo-Romero</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Querol Garcia, Javier" sort="Querol Garcia, Javier" uniqKey="Querol Garcia J" first="Javier" last="Querol-García">Javier Querol-García</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
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<author><name sortKey="Culebras, Esther" sort="Culebras, Esther" uniqKey="Culebras E" first="Esther" last="Culebras">Esther Culebras</name>
<affiliation wicri:level="3"><nlm:affiliation>Microbiology Department Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Microbiology Department Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Urcelay, Elena" sort="Urcelay, Elena" uniqKey="Urcelay E" first="Elena" last="Urcelay">Elena Urcelay</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernández-Pérez">Cristina Fernández-Pérez</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Research and Methodology Unit, Facultad de Medicina, Hospital Clínico San Carlos Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Clinical Research and Methodology Unit, Facultad de Medicina, Hospital Clínico San Carlos Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
<orgName type="university">Université complutense de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Sanchez Fructuoso, Ana Isabel" sort="Sanchez Fructuoso, Ana Isabel" uniqKey="Sanchez Fructuoso A" first="Ana Isabel" last="Sánchez-Fructuoso">Ana Isabel Sánchez-Fructuoso</name>
<affiliation wicri:level="4"><nlm:affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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</placeName>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles (MeSH)</term>
<term>Cytokines (genetics)</term>
<term>Cytokines (metabolism)</term>
<term>Cytomegalovirus Infections (diagnosis)</term>
<term>Cytomegalovirus Infections (epidemiology)</term>
<term>Cytomegalovirus Infections (etiology)</term>
<term>Cytomegalovirus Infections (prevention & control)</term>
<term>Disease Susceptibility (MeSH)</term>
<term>Genetic Predisposition to Disease (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Interferon-gamma (genetics)</term>
<term>Kidney Transplantation (adverse effects)</term>
<term>Kidney Transplantation (methods)</term>
<term>Polymorphism, Single Nucleotide (MeSH)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles (MeSH)</term>
<term>Cytokines (génétique)</term>
<term>Cytokines (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infections à cytomégalovirus (diagnostic)</term>
<term>Infections à cytomégalovirus (prévention et contrôle)</term>
<term>Infections à cytomégalovirus (épidémiologie)</term>
<term>Infections à cytomégalovirus (étiologie)</term>
<term>Interféron gamma (génétique)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Polymorphisme de nucléotide simple (MeSH)</term>
<term>Prédisposition aux maladies (MeSH)</term>
<term>Prédisposition génétique à une maladie (MeSH)</term>
<term>Transplantation rénale (effets indésirables)</term>
<term>Transplantation rénale (méthodes)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term>
<term>Interferon-gamma</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Kidney Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cytomegalovirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à cytomégalovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation rénale</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cytomegalovirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cytomegalovirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term>
<term>Interféron gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Kidney Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Transplantation rénale</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cytomegalovirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à cytomégalovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à cytomégalovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à cytomégalovirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Disease Susceptibility</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Incidence</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Proportional Hazards Models</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allèles</term>
<term>Humains</term>
<term>Incidence</term>
<term>Modèles des risques proportionnels</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition aux maladies</term>
<term>Prédisposition génétique à une maladie</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en">The +874 A/T polymorphism in the interferon gamma (<i>IFNG</i>
) gene has been associated with Cytomegalovirus (CMV) infection risk in lung and kidney transplant recipients. To replicate this association, we performed a retrospective observational study of this polymorphism and immunosuppressive therapies considering the prophylactic treatment in 600 consecutive kidney transplanted recipients. We found no association of the aforementioned polymorphism with CMV infection in univariate and multivariate analyses regardless of the prophylactic treatment. In addition, the immunosuppressive treatment with mammalian target of rapamycin inhibitors (imTOR) showed a protective effect in all patients independently of prophylaxis. Moreover, in the adjusted model, we found interactions between prophylaxis with high-risk (Donor+/Recipient-, D+/R-) status (<i>p</i>
-interaction = 0.01), with thymoglobulin induction therapy (<i>p</i>
-interaction = 0.03) and with thymoglobulin anti-rejection therapy (<i>p</i>
-interaction = 0.002). Data also revealed that prophylaxis was not an advantage in the not D+/R- and without thymoglobulin therapy group (HR = 0.98, <i>p</i>
 = 0.95). The benefit of prophylaxis was observed in all groups with thymoglobulin therapy, but it was maximal in the high-risk CMV infection group with both thymoglobulin induction therapy and thymoglobulin anti-rejection therapy (HR = 0.01, <i>p</i>
 < 0.001). In conclusion, the <i>IFNG</i>
 +874 polymorphism is not a predictive marker of CMV infection. The protective effect of imTOR is not improved with prophylaxis. Interestingly, the thymoglobulin therapy associated with prophylaxis is not a risk factor for CMV infection, and prophylaxis is not effective in recipients with no high-risk CMV status and without thymoglobulin therapy.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31998298</PMID>
<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1664-3224</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Frontiers in immunology</Title>
<ISOAbbreviation>Front Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>The Interferon-Gamma +874 A/T Polymorphism Is Not Associated With CMV Infection After Kidney Transplantation.</ArticleTitle>
<Pagination><MedlinePgn>2994</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3389/fimmu.2019.02994</ELocationID>
<Abstract><AbstractText>The +874 A/T polymorphism in the interferon gamma (<i>IFNG</i>
) gene has been associated with Cytomegalovirus (CMV) infection risk in lung and kidney transplant recipients. To replicate this association, we performed a retrospective observational study of this polymorphism and immunosuppressive therapies considering the prophylactic treatment in 600 consecutive kidney transplanted recipients. We found no association of the aforementioned polymorphism with CMV infection in univariate and multivariate analyses regardless of the prophylactic treatment. In addition, the immunosuppressive treatment with mammalian target of rapamycin inhibitors (imTOR) showed a protective effect in all patients independently of prophylaxis. Moreover, in the adjusted model, we found interactions between prophylaxis with high-risk (Donor+/Recipient-, D+/R-) status (<i>p</i>
-interaction = 0.01), with thymoglobulin induction therapy (<i>p</i>
-interaction = 0.03) and with thymoglobulin anti-rejection therapy (<i>p</i>
-interaction = 0.002). Data also revealed that prophylaxis was not an advantage in the not D+/R- and without thymoglobulin therapy group (HR = 0.98, <i>p</i>
 = 0.95). The benefit of prophylaxis was observed in all groups with thymoglobulin therapy, but it was maximal in the high-risk CMV infection group with both thymoglobulin induction therapy and thymoglobulin anti-rejection therapy (HR = 0.01, <i>p</i>
 < 0.001). In conclusion, the <i>IFNG</i>
 +874 polymorphism is not a predictive marker of CMV infection. The protective effect of imTOR is not improved with prophylaxis. Interestingly, the thymoglobulin therapy associated with prophylaxis is not a risk factor for CMV infection, and prophylaxis is not effective in recipients with no high-risk CMV status and without thymoglobulin therapy.</AbstractText>
<CopyrightInformation>Copyright © 2020 Santiago, Pérez-Flores, Sánchez-Pérez, Moreno de la Higuera, Calvo-Romero, Querol-García, Culebras, Urcelay, Fernández-Pérez and Sánchez-Fructuoso.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Santiago</LastName>
<ForeName>Jose Luis</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez-Flores</LastName>
<ForeName>Isabel</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sánchez-Pérez</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moreno de la Higuera</LastName>
<ForeName>Maria Angeles</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calvo-Romero</LastName>
<ForeName>Natividad</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Querol-García</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Culebras</LastName>
<ForeName>Esther</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Microbiology Department Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Urcelay</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernández-Pérez</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Clinical Research and Methodology Unit, Facultad de Medicina, Hospital Clínico San Carlos Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sánchez-Fructuoso</LastName>
<ForeName>Ana Isabel</ForeName>
<Initials>AI</Initials>
<AffiliationInfo><Affiliation>Nephrology Department Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>01</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Front Immunol</MedlineTA>
<NlmUniqueID>101560960</NlmUniqueID>
<ISSNLinking>1664-3224</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>82115-62-6</RegistryNumber>
<NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="Y">Alleles</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003586" MajorTopicYN="N">Cytomegalovirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004198" MajorTopicYN="Y">Disease Susceptibility</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016030" MajorTopicYN="N">Kidney Transplantation</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">IFNG polymorphism</Keyword>
<Keyword MajorTopicYN="Y">cytomegalovirus</Keyword>
<Keyword MajorTopicYN="Y">immunosuppression</Keyword>
<Keyword MajorTopicYN="Y">kidney transplantation</Keyword>
<Keyword MajorTopicYN="Y">prophylaxis</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>09</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>12</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>1</Month>
<Day>31</Day>
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<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
</settlement>
<orgName><li>Université complutense de Madrid</li>
</orgName>
</list>
<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Santiago, Jose Luis" sort="Santiago, Jose Luis" uniqKey="Santiago J" first="Jose Luis" last="Santiago">Jose Luis Santiago</name>
</region>
<name sortKey="Calvo Romero, Natividad" sort="Calvo Romero, Natividad" uniqKey="Calvo Romero N" first="Natividad" last="Calvo-Romero">Natividad Calvo-Romero</name>
<name sortKey="Culebras, Esther" sort="Culebras, Esther" uniqKey="Culebras E" first="Esther" last="Culebras">Esther Culebras</name>
<name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernández-Pérez">Cristina Fernández-Pérez</name>
<name sortKey="Moreno De La Higuera, Maria Angeles" sort="Moreno De La Higuera, Maria Angeles" uniqKey="Moreno De La Higuera M" first="Maria Angeles" last="Moreno De La Higuera">Maria Angeles Moreno De La Higuera</name>
<name sortKey="Perez Flores, Isabel" sort="Perez Flores, Isabel" uniqKey="Perez Flores I" first="Isabel" last="Pérez-Flores">Isabel Pérez-Flores</name>
<name sortKey="Querol Garcia, Javier" sort="Querol Garcia, Javier" uniqKey="Querol Garcia J" first="Javier" last="Querol-García">Javier Querol-García</name>
<name sortKey="Sanchez Fructuoso, Ana Isabel" sort="Sanchez Fructuoso, Ana Isabel" uniqKey="Sanchez Fructuoso A" first="Ana Isabel" last="Sánchez-Fructuoso">Ana Isabel Sánchez-Fructuoso</name>
<name sortKey="Sanchez Perez, Luis" sort="Sanchez Perez, Luis" uniqKey="Sanchez Perez L" first="Luis" last="Sánchez-Pérez">Luis Sánchez-Pérez</name>
<name sortKey="Urcelay, Elena" sort="Urcelay, Elena" uniqKey="Urcelay E" first="Elena" last="Urcelay">Elena Urcelay</name>
</country>
</tree>
</affiliations>
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The Interferon-Gamma +874 A/T Polymorphism Is Not Associated With CMV Infection After Kidney Transplantation.

The Interferon-Gamma +874 A/T Polymorphism Is Not Associated With CMV Infection After Kidney Transplantation.

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